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Model for integrin α3β1 signaling to Arg kinase in hippocampal dendritic spines. Integrin α3β1 (1) is activated by an unknown upstream extracellular ligand. The intracellular tail of β1 binds to and activates Arg kinase, Arg phosphorylates p190 (2), phosphorylated p190 forms a complex with p120 at the postsynaptic membrane (3), and the p120/p190 complex inhibits RhoA GTPase activity (4) and promotes the stability of neuronal morphology (5).
