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. Author manuscript; available in PMC: 2013 Dec 1.
Published in final edited form as: Nat Immunol. 2013 May 5;14(6):611–618. doi: 10.1038/ni.2607

Figure 5.

Figure 5

Isoform-specific deletion of Akt2 affects iTH17 cell differentiation. (a) IL-17 producing thymocytes from WT, Akt1−/−and Akt2−/− mice following ex vivo stimulation. Representative flow plots are gated on CD4SPTCRβ+TCRγδ− cells, and graphed data are pooled from three independent experiments (n = 5–8; mean ± SEM; ns, not significant from one-way ANOVA followed by Bonferroni’s post-test). (b) IL-17 producing small intestinal LP cells from WT, Akt1−/− and Akt2−/− mice following ex vivo stimulation. Representative flow plots are gated on CD4+CD3+TCRβ+ cells, and graphed data are pooled from three independent experiments (n = 3–4; mean ±SEM; NS, not significant; *P≤0.001 from one-way ANOVA followed by Bonferroni’s post-test).