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Model of TPI function and pathogenesis. The results of this study suggest that TPI has catalytic (orange) and non-catalytic (blue) functions. Impairment of TPI function (yellow) was studied in vivo using K11M (abolishes catalytic activity) and sgk (leads to protein degradation). The data demonstrate the presence of a non-isomerase TPI function required for normal neural function and suggests that loss of this function underlies neuropathogenesis in TPI deficiency.
