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. Author manuscript; available in PMC: 2014 May 15.
Published in final edited form as: Clin Cancer Res. 2013 Mar 27;19(10):2699–2709. doi: 10.1158/1078-0432.CCR-12-2671

Figure 1. Correlation of MGMT status, cell viability, and DNA damage response in MP cells following exposure to 6BG/TMZ.

Figure 1

(A) Human MP cells were exposed to 6BG in the absence or presence of TMZ (200 uM and 400 uM) and 6BG/TMZ for one day and probed for MGMT expression. Beta-actin served as loading (B) MP cells were treated in triplicate and viability of myeloid cultures determined over time. (C-E). Analysis of 6BG/TMZ-induced p53 stabilization, p21, AKT phosphorylation, and cell cycle arrest at Day 3 post-treatment. GAPDH served as a loading control. *p < 0.05, 6BG/TMZ vs. control, 6BG, or TMZ. Data are representative of 3 independent experiments.