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. Author manuscript; available in PMC: 2013 Jul 15.
Published in final edited form as: J Child Psychol Psychiatry. 2010 Apr 12;51(8):935–943. doi: 10.1111/j.1469-7610.2010.02245.x

Figure 1.

Figure 1

Potential neurotoxic consequences of kynurenine pathway activation resulting from peripheral induction of indoleamine 2,3-dioxygenase (IDO). Asterisks represent pathway metabolites that cross the blood-brain barrier. TRP, tryptophan; KYN, kynurenine; IFN, interferon; IL, interleukin; 3-HK, 3-hydroxykynurenine; 3-HAA, 3-hydroxyanthranilic acid; QUIN, quinolinic acid; KA, kynurenic acid; NMDA, N-methyl- D-aspartate; GABA, γ-aminobutyric acid