Table 1.

Demographic and Clinical Characteristics of Adolescents With MDD and Healthy Controls

	Mean (SD) [Range]
	All MDD (n = 20)	Anhedonic MDD (n = 10)	Nonanhedonic MDD (n = 10)	Healthy Controls (n = 21)
Characteristic
Age, y	16.7 (2.7) [12–19]	18.0 (1.9) [14–19]^a	15.3 (2.7) [12–19]^a	16.2 (1.6) [13–19]
Sex, No. (%)
M	8 (40)	4 (40)	4 (40)	6 (32)
F	12 (60)	6 (60)	6 (60)	15 (68)
IQ	106.2 (11.3)	109.8 (10.7)^a	102.5 (11.2)^a	110.0 (11.6)
Ethnicity, No. (%)
White	8 (40)	5 (50)	3 (30)	9 (43)
African American	2 (10)	0	2 (20)	7 (33)
Hispanic	8 (40)	3 (30)	5 (50)	0
Asian	0	0	0	3 (14)
Other	2 (10)	2 (20)	0	2 (10)
Illness history
Episode duration, mo	11.7 (8.6) [2–36]	13.1 (10.7) [4–36]	10.2 (6.0) [2–21]	0
No. of episodes	1.4 (0.6) [1–3]	1.6 (0.7) [1–3]	1.2 (0.4) [1–2]	0
Suicide attempts	0.3 (0.6) [0–2]	0.1 (0.3) [0–1]	0.4 (0.7) [0–2]	0
Medication naive, No. (%)	15 (75)	6 (60)	9/1 (90)	21 (100)
Medication free, No. (%)	5 (25)	4 (40)	1 (10)	0
Melancholic subtype, No. (%)	3 (15)	3 (30)	0	0
CDRS-R score	52.6 (7.5) [38–68]	56.9 (6.9) [43–68]^a	48.3 (5.5) [38–58]^a	18.8 (1.1) [17–21]
BDI-II score	30.1 (12.7) [12–51]	31.8 (13.6) [17–51]	28.4 (12.2) [12–47]	2.6 (3.0) [0–10]
Anhedonia score	7.7 (2.5) [3–11]	8.3 (2.2) [5–11]	7.0 (2.6) [3–11]	1.3 (0.6) [1–3]
Current comorbidity, No. (%)
ADHD	4 (20)	2 (20)	2 (20)	0
Any anxiety disorder	11 (55)	6 (60)	5 (50)	0
GAD	11 (55)	6 (60)	5 (50)	0

Abbreviations: ADHD, attention-deficit/hyperactivity disorder; BDI-II; Beck Depression Inventory, second edition; CDRS-R; Children’s Depression Rating Scale–Revised; GAD, generalized anxiety disorder; MDD, major depressive disorder.

Anhedonic and nonanhedonic MDD subgroups differed significantly with respect to age (P = .02), ethnicity, and MDD severity (P = .007).