Table 4.
Distant metastasis subgroup: effects of age, number of comorbid conditions, time since distant metastasis diagnosis and type of medical treatment on outcomes (n = 298)
| Outcome | Effects | Estimate | SE | P-value |
|---|---|---|---|---|
| Physical function | Age | –0.2181 | 0.1471 | 0.1394 |
| # of comorbid conditions | –6.3656 | 1.5834 | <0.0001** | |
| # of months since metastasis diagnosis | –0.0260 | 0.0513 | 0.6136 | |
| Chemotherapy compared to hormonal | –15.2854 | 5.0515 | 0.0027* | |
| CES-D | Age | –0.1160 | 0.0508 | 0.0233* |
| # of comorbid conditions | 1.2463 | 0.5466 | 0.0234* | |
| # of months since metastasis diagnosis | 0.0084 | 0.0176 | 0.6320 | |
| Chemotherapy compared to hormonal | 2.4462 | 1.7305 | 0.1587 | |
| Anxiety | Age | –0.1013 | 0.0591 | 0.0876 |
| # of comorbid conditions | 0.7564 | 0.6354 | 0.2349 | |
| # of months since metastasis diagnosis | –0.0005 | 0.0205 | 0.9820 | |
| Chemotherapy compared to hormonal | –0.1129 | 2.0158 | 0.9554 | |
| Pain (BPI) | Age | –0.0280 | 0.0154 | 0.0696 |
| # of comorbid conditions | 0.4164 | 0.1650 | 0.0122* | |
| # of months since metastasis diagnosis | 0.0092 | 0.0053 | 0.0853 | |
| Chemotherapy compared to hormonal | 0.8970 | 0.5227 | 0.0873 | |
| Fatigue (BFI) | Age | –0.0118 | 0.0138 | 0.3934 |
| # of comorbid conditions | 0.0954 | 0.1481 | 0.5200 | |
| # of months since metastasis diagnosis | 0.0010 | 0.0047 | 0.8274 | |
| Chemotherapy compared to hormonal | 0.6968 | 0.4675 | 0.1373 | |
| Shortness of breath (FACT-B item) | Age | –0.0097 | 0.0058 | 0.0950 |
| # of comorbid conditions | –0.1269 | 0.0625 | 0.0432* | |
| # of months since metastasis diagnosis | –0.0044 | 0.0020 | 0.0308* | |
| Chemotherapy compared to hormonal | –0.1933 | 0.1977 | 0.3291 | |
| Nausea (FACT-B item) | Age | 0.0109 | 0.0046 | 0.0180* |
| # of comorbid conditions | –0.0516 | 0.0492 | 0.2957 | |
| # of months since metastasis diagnosis | –0.0018 | 0.0016 | 0.2641 | |
| Chemotherapy compared to hormonal | –0.0571 | 0.1547 | 0.7126 | |
| Sleep (FACT-B item) | Age | 0.0113 | 0.0059 | 0.0554 |
| # of comorbid conditions | –0.0410 | 0.0632 | 0.5171 | |
| # of months since metastasis diagnosis | 0.0000 | 0.0020 | 0.9837 | |
| Chemotherapy compared to hormonal | –0.2008 | 0.1997 | 0.3156 | |
| LTQL – spiritual subscale | Age | 0.0665 | 0.0347 | 0.0560 |
| # of comorbid conditions | 0.2855 | 0.3729 | 0.4447 | |
| # of months since metastasis diagnosis | –0.0122 | 0.0121 | 0.3111 | |
| Chemotherapy compared to hormonal | –0.4388 | 1.1859 | 0.7117 |
*
P < 0.05
**
P < 0.01.
CES-D, Center for Epidemiologic Studies Depression Scale; BPI, Brief Pain Inventory; BFI, Brief Fatigue Inventory; FACT-B, Functional Assessment of Cancer Therapy-Breast Scale-Version 4; LTQL, Long-Term Quality of Life Instrument.