Table 1.

Effect of asenapine on dopamine and serotonin turnover in brain

DOPAMINE TURNOVER
REGION	SALINE-SALINE	SALINE-ASENAPINE 150
caudate nucleus	0.87 ± 0.04	1.33 ± 0.08*
putamen	1.15 ± 0.12	1.72 ± 0.04*
prelimbic cortex	2.79 ± 0.17	4.97 ± 0.33*
premotor cortex	2.93 ± 0.18	4.23 ± 0.38*
frontal eye field	7.00 ± 0.43	10.9 ± 1.47*

SEROTONIN TURNOVER
REGION	SALINE-SALINE	SALINE-ASENAPINE 150
caudate nucleus	1.50 ± 0.10	2.37 ± 0.19*
putamen	2.28 ± 0.24	3.28 ± 0.44*
prelimbic cortex	0.43 ± 0.03	0.69 ± 0.08*
premotor cortex	0.37 ± 0.02	0.56 ± 0.05*
frontal eye field	0.46 ± 0.07	0.70 ± 0.06*
medial prefrontal cortex	0.37 ± 0.03	0.59 ± 0.06*
supplementary motor cortex	0.34 ± 0.02	0.84 ± 0.21*
primary motor cortex	0.49 ± 0.05	0.73 ± 0.07*
amygdala	0.66 ± 0.06	1.00 ± 0.08*
hippocampus	0.89 ± 0.13	2.37 ± 0.18*

Saline-Saline group was treated with saline twice daily for 6 weeks.

Saline-asenapine group was treated with saline twice daily for 2 weeks, followed by asenapine twice daily (150 μg/kg) for 4 weeks.

^*significantly different from saline-saline group (2-way unpaired t-test, p<0.05) 8 monkeys in each group