Table 2.
Summary of clinical lab values for CF patients with severe liver disease
| Study | Number of Patients a |
% of patients | |||
|---|---|---|---|---|---|
| Normal range | > 1X to ≤ 2X | > 2X | |||
|
Aspartate transaminase (AST) (range of values) |
Initial | 122 | 23.0 | 43.4 | 33.6 |
| Replication | 132 | 16.7 | 47.7 | 35.6 | |
| (≤ 30 U/L) | (31–60 U/L) | (> 60 U/L) | |||
|
Alanine transaminase (ALT) (range of values) |
Initial | 116 | 47.4 | 35.3 | 17.2 |
| Replication | 133 | 44.4 | 37.6 | 18.0 | |
| (≤ 40 U/L) | (41–80 U/L) | (> 80 U/L) | |||
|
Gamma glutamyl transferase (GGT) (range of values) |
Initial | 110 | 24.5 | 16.4 | 59.1 |
| Replication | 114 | 19.3 | 28.1 | 52.6 | |
| (≤ 30 U/L) | (31–60 U/L) | (> 60 U/L) | |||
|
Total bilirubin (T Bili) b (range of values) |
Initial | 106 | 66.0 | 18.9 | 15.1 |
| Replication | 111 | 70.3 | 17.1 | 12.6 | |
| (≤ 1.2 mg/dl) | (1.3–2.4 mg/dl) | (> 2.4 mg/dl) | |||
| Normal range | Low | Very Low | |||
|
Albumin c (range of values) |
Initial | 104 | 49.0 | 42.3 | 8.7 |
| Replication | 120 | 56.7 | 39.2 | 4.1 | |
| (≥ 3.5 g/dl) | (2.5–3.4 g/dl) | (< 2.5 g/dl) | |||
| Normal range | Moderately High | High | |||
|
International normalized ratio (INR) (range of values) |
Initial | 88 | 28.4 | 51.1 | 20.5 |
| Replication | 90 | 32.2 | 47.8 | 20.0 | |
| (< 1.2) | (1.2–1.5) | (> 1.5) | |||
a
Number of patients with data available.
b
Total bilirubin abnormal in 40.9% of patients (9 out of 22) in Initial Study and 38.1% of patients (8 out of 21) in Replication Study, just prior to liver transplant.
c
Albumin abnormal in 61.9% of patients (13 out of 21) in Initial Study and 50.0% of patients (10 out of 20) in Replication Study, just prior to liver transplant.