Fig. 14.4.

The PCNA clamp opens in a right-handed spiral. (a) Molecular simulations indicate that PCNA opens in a right-handed spiral that matches the shape of the RFC AAA+ domains (top diagram); the model of open PCNA with the structure of RFC is shown below (Kazmirski et al. 2005) (Reproduced with permission from Figure 5 of Kazmirski et al. (2005)). (b) Electron micro-graph particle reconstruction of an archaeal RFC-PCNA in the presence of DNA and ATP (Miyata et al. 2005) (Reproduced with permission from Figure 3a in Miyata et al. (2005))