Lineweaver-Burk plot (A) and Dixon plot (B) for compound 8b–mediated LYP inhibition using pNPP as a substrate. pNPP concentrations were 1.17, 1.76, 2.63, 3.95, 5.93, 8.89, 13.3, and 20 mM. Compound 8b concentrations were 0 (•), 75 (μ), 150 (τ), and 225 (∇) nM, respectively.