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. Author manuscript; available in PMC: 2014 Jun 27.
Published in final edited form as: J Med Chem. 2013 Jun 6;56(12):4990–5008. doi: 10.1021/jm400248c

Figure 8.

Figure 8

Compound 8b binding site comparison between LYP and other PTPs. The PTP active sites and the peripheral pockets are depicted by electrostatic surface representation prepared by PyMol (The PyMOL Molecular Graphics System, Version 1.4.1 Schrödinger, LLC.). The binding site for the substituted phenyl group at the 2-position of benzofuran ring was marked by a red circle, and the binding site for the 3-chlorophenyl ring attached to the 3-ethynyl group in the benzofuran ring was marked by a yellow circle. Compound 8b is shown in stick model colored according to electrostatic properties of atoms.