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IC50 of Core 1-based analogues (4a–i) against LYP.
 | ||
|---|---|---|
| Cmpd # | R2 = | IC50 (µM) |
| 4a | H | 4.9 ± 0.3 |
| 4b | 3-F | 3.9 ± 0.2 |
| 4c | 3-Cl | 1.0 ± 0.07 |
| 4d | 3-OCH3 | 17 ± 1 |
| 4e | 2,4-di-F | 3.5 ± 0.2 |
| 4f | 3,5-di-F | 1.3 ± 0.1 |
| 4g | 3-CF3 | 2 ± 0.1 |
| 4h | 4-OCF3 | 2 ± 0.1 |
| 4i | 4-OC6H5 | 0.63 ± 0.03 |
