Table 5.

IC₅₀ values of 8a and 8b against a panel of PTPs.

PTP	IC50 (µM) for 8a	IC50 (µM) for 8b
LYP	0.171 ± 0.004	0.259 ± 0.007
PTP1B	1.7 ± 0.4	10 ± 1
SHP1	0.91 ± 0.09	5 ± 0.5
SHP2	0.56 ± 0.03	2.5 ± 0.1
TC-PTP	11.3 ± 0.5	24 ± 1
HePTP	3 ± 0.6	15 ± 2
PTP-Meg2	0.59 ± 0.03	3 ± 0.3
FAP1	0.39 ± 0.02	2.9 ± 0.2
PTP-PEST	0.80 ± 0.10	2.4 ± 0.3
PTPH1	1.6 ± 0.6	13 ± 4
CD45	3.2 ± 0.6	12 ± 5
LAR	No inhibition at 100 µM	No inhibition at 100 µM
PTPα	No inhibition at 100 µM	No inhibition at 100 µM
PTPβ	0.47 ± 0.05	12 ± 5
PTPε	>25	>25
PTPγ	4 ± 2	15 ± 6
PTPµ	7 ± 1	12 ± 2
PTPσ	No inhibition at 100 µM	No inhibition at 100 µM
Laforin	No inhibition at 100 µM	No inhibition at 100 µM
VHR	5.9 ± 0.5	14 ± 1
VHX	2.9 ± 0.6	4.6 ± 0.7
VHZ	3.4 ± 0.3	5.7 ± 0.7
MKP3	No inhibition at 100 µM	No inhibition at 100 µM
CDC14	30 ± 10	24 ± 2
LMWPTP	0.34 ± 0.07	7 ± 2

All measurements were made by using pNPP as a substrate at pH 7.0, 25°C, and ionic strength of 0.15 M.