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. Author manuscript; available in PMC: 2013 Jul 15.
Published in final edited form as: J Immunol. 2009 May 1;182(9):5317–5321. doi: 10.4049/jimmunol.0803868

Figure 2.

Figure 2

IL-13 attenuates IL-17A production from Th17 differentiated T cells in WT and IL-4 KO mice but not IL-4R KO and STAT6 KO mice. IL-4 or IL-13 (0 – 10 ng/ml) was added at the time of Th17 polarization and cultured supernatants were collected 4 days after polarization, and examined for IL-17A (panel A) and IL-21 (panel B) protein production. (C) T cells were polarized to Th17 cells and restimulated with plate-bound anti-CD3 in the presence of IL-4 or IL-13 (0 – 10 ng/ml) and IL-17A protein production was measured 24 h after restimulation. (D) WT, IL-4 KO, IL-4R KO, and STAT6 KO CD4+ T cells were polarized to Th17 cells in the presence of IL-13 and IL-17A protein production was measured 4 days after polarization. Data is compiled from 3 separate experiments, n = 6–14, * p < 0.05 compared to Th17 cells (no IL-13) from respective strain of mice; † p< 0.05 compared to Th17 cells (no IL-13) from WT mice, ANOVA.

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