TABLE 5.
Blunted catabolic response to continuous PTH administration in Ocy-PPRKO detected by histomorphometric analysis in femurs
Values are mean ± S.E., ANOVA with Tukey/Kramer.
| Parameter | Control vehicle, N = 9 | Control PTH, N = 8 | Ocy-PPRKO vehicle, N = 8–9 | Ocy-PPRKO PTH, N = 8 | ANOVA p value |
|---|---|---|---|---|---|
| BV/TV (%) | 11.17 ± 0.97 | 10.29 ± 1.23 | 15.39 ± 0.62a,b | 13.19 ± 1.24 | 0.02 |
| Tb.Th (μm) | 33.78 ± 1.70 | 34.05 ± 2.21 | 37.24 ± 1.29 | 36.85 ± 2.07 | 0.4 |
| Tb.N (mm) | 3.27 ± 0.16 | 3.17 ± 0.17 | 4.13 ± 0.10a,b | 3.53 ± 0.18c | 0.000 |
| Tb.Sp (μm) | 278.8 ± 18.1 | 287.8 ± 18.3 | 206 ± 6.5a,b | 252.1 ± 17.5 | 0.003 |
| Ob.S/BS (%) | 8.35 ± 1.83 | 24.94 ± 5.54a | 2.45 ± 1.19b | 7.37 ± 1.64b | 0.000 |
| N.Ob/T.Ar (mm2) | 41.40 ± 8.30 | 129.59 ± 32.59a | 15.22 ± 7.03b | 38.80 ± 8.49b | 0.000 |
| N.Ob/B.Pm (mm) | 6.51 ± 1.32 | 19.89 ± 4.60a | 1.80 ± 0.79b | 5.72 ± 1.27b | 0.000 |
| OV/TV (%) | 0.062 ± 0.013 | 0.230 ± 0.076a | 0.010 ± 0.003b | 0.036 ± 0.012b | 0.002 |
| OS/BS (%) | 3.30 ± 0.7 | 10.62 ± 3.5a | 0.47 ± 0.1b | 1.71 ± 0.5b | 0.002 |
| O.Th (μm) | 3.00 ± 0.20 | 3.32 ± 0.21 | 2.46 ± 0.48 | 2.94 ± 0.36 | 0.348 |
| Oc.S/BS (%) | 1.26 ± 0.28 | 3.43 ± 0.56a | 0.72 ± 0.23b | 1.27 ± 0.23b | 0.000 |
| N.Oc/T.Ar (mm2) | 2.72 ± 0.52 | 8.51 ± 1.68a | 2.42 ± 0.73b | 3.37 ± 0.67b | 0.000 |
| N.Oc/B.Pm (mm) | 0.44 ± 0.09 | 1.29 ± 0.21a | 0.30 ± 0.09b | 0.49 ± 0.10b | 0.000 |
| ES/BS (%) | 0.43 ± 0.10 | 1.26 ± 0.26a | 0.26 ± 0.12b | 0.57 ± 0.14b | 0.001 |
a p < 0.05 compared with control vehicle.
b p < 0.05 compared with control PTH.
c p < 0.05 compared with Ocy-PPRKO.