TABLE 2.

Correlation of UBX-Cter mRNA abundance and effects

UBX-Cter mRNA abundances are given relative to endogenous TUG mRNA abundances in the identical tissues of wild type mice (as plotted in Fig. 1B). Cleavage indicates the abundance ratio of the 42-kDa cleavage product to total (i.e. 60- + 42-kDa) TUG proteins (as in Fig. 1H). 2DOG uptake is the ratio of fasting, tissue-specific 2-deoxyglucose uptake in transgenic versus wild type control muscles, which was significant in quadriceps (p < 0.02; Fig. 3F) but not in other muscles. Glycogen is normalized per mg of protein in each muscle and is given as the increase relative to that in wild type control muscles (Fig. 4A). Gastroc., gastrocnemius; TA, tibialis anterior; ND, not done; NS, not significant.

	Quadriceps	Gastroc.	TA	Soleus
UBX-Cter mRNA	112 ± 29	70 ± 9	39 ± 16	3 ± 0.6
Cleavage (product/total)	0.73 ± 0.15	∼0.01 (NS)	∼0.01 (NS)	ND
2DOG uptake (-fold increase in TG vs. WT)	2.7	1.2 (NS)	1.1 (NS)	ND
Glycogen (-fold increase in TG vs. WT)	2.1 ± 0.3	1.7 ± 0.2	1.7 ± 0.1	1.0 ± 0.1 (NS)