FIGURE 1.

Schematic representation of pantothenate transport and CoA biosynthesis in P. falciparum-infected erythrocytes. Pantothenate is transported across the plasma membrane by the parasite pantothenate transporter and converted into CoA by the enzymes pantothenate kinase (1), phosphopantothenoylcysteine synthetase (2), phosphopantothenoylcysteine decarboxylase (3), phosphopantotheine adenyltransferase (4), and dephospho-CoA kinase (5). PPM, parasite plasma membrane; PVM, parasitophorous vacuolar membrane; RBCM, red blood cells membrane.