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Essential role of exogenous pantothenate in P. falciparum intraerythrocytic development. Growth of P. falciparum parasites in the absence (pantothenic acid-free medium) (A) or presence of 10 μm (B), 100 μm (C), and 200 μm (D) pantothenate is shown. Parasite cultures were initiated at 1% parasitemia and 2% hematocrit and maintained for three developmental cycles. Cultures were diluted at days 3 and 6 to 1% when parasitemia reached 8–10%.
