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Coordination at the mouth of the LRH-1 LBP is important for receptor activation. A, mlLRH-1. B, mLRH-1 (PDB ID: 3PK5). C, hLRH-1 bound to an activating phosphatidylcholine (PDB ID: 4DOS). D, hLRH-1 bound to a small molecule agonist (PDB ID: 3PLZ).
