Table 2 .
Sensitivity, specificity, PPV and NPV (95% CIs in parentheses) of 2010 ACR/EULAR and 1987 ACR classification criteria in patients with very early inflammatory arthritis.
| 2010 ACR/EULAR classification criteria | 2010 ACR/EULAR classification criteria* | 1987 ACR classification criteria | |||||||
|---|---|---|---|---|---|---|---|---|---|
| DMARD start | Diagnosis: RA | Diagnosis: RA and/or DMARD Start† | DMARD start | Diagnosis: RA | Diagnosis: RA and/or DMARD Start†,‡ | DMARD start | Diagnosis: RA | Diagnosis: RA and/or DMARD Start† | |
| Sensitivity | 0.80 (0.73–0.86) | 0.85 (0.78–0.90) | 0.79 (0.73–0.85) | 0.80 (0.74–0.86) | 0.85 (0.78–0.90) | 0.80 (0.73–0.85) | 0.55 (0,47–0.63) | 0.65 (0.56–0.73) | 0.57 (0.50–0.64) |
| Specificity | 0.63 (0.55–0.71) | 0.64 (0.56–0.71) | 0.66 (0.58–0.74) | 0.61 (0.53–0.70) | 0.64 (0.55–0.73) | 0.64 (0.56–0.73) | 0.76 (0.67–0.83) | 0.80 (0.72–0.86) | 0.80 (0.72–0.87) |
| PPV | 0.71 (0.65–0.78) | 0.68 (0.62–0.77) | 0.75 (0.69–0.82) | 0.82 (0.76–0,87) | 0.74 (0.64–0.78) | 0.78 (0.69–0.82) | 0.71 (0.62–0.79) | 0.73 (0.64–0.80) | 0.78 (0.70–0,85) |
| NPV | 0.73 (0.66–0.81) | 0.82 (0.76–0.87) | 0.70 (0.63–0.76) | 0.71 (0.66–0.81) | 0.78 (0.72–0.87) | 0.68 (0.63–0.76) | 0.60 (0.52–0.68) | 0.73 (0.65–0.80) | 0.59 (0.53–0.66) |
*35 patients excluded because of ‘other better explanations’, that is, diagnosis of specific non-RA-disease within 3 months.
†this category comprises all RA patients (including 10 patients who declined DMARD and/or had contra-indications) and 27 DMARD treated patients with other diagnoses or UA
‡(n = 17 after exclusion of ‘other better explanations’).
ACR, American College of Rheumatology; DMARD, disease-modifying antirheumatic drug; EULAR, European League Against Rheumatism; NPV, negative predictive value; PPV, positive predictive value; RA, rheumatoid arthritis.