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. Author manuscript; available in PMC: 2014 Jan 1.
Published in final edited form as: Annu Rev Pharmacol Toxicol. 2012 Sep 27;53:59–87. doi: 10.1146/annurev-pharmtox-010611-134540

Figure 1. Effect of stress on DNA methylation and gene expression.

Figure 1

Cartoon of sagittal section of rodent brain depicts several inter-connected regions that have been implicated in stress responses (top). Table (bottom) lists the small number of specific genes whose methylation has been shown to date to be altered by stress, the brain regions in which this regulation occurs, and the type of stress involved. Transcriptional mechanisms associated with such altered DNA methylation are listed under Associated Mechanisms. Arrows indicate increase (red) or decrease (green) in gene expression (left) or methylation (right). References are in superscript. Hipp, hippocampus; PFC, prefrontal cortex; PVN, paraventricular nucleus of hypothalamus; NAc, nucleus accumbens; AMY, amygdala; VTA, ventral tegmental area; DR, dorsal raphe; LC, locus coeruleus; Sus, susceptible; Res, resilient.