Table 1.

Myelin-related genes used in qPCR analysis comparing gene expression of Klotho^−/− and Klotho^+/+ mice brain samples at 8 weeks of age

Symbol	Description	Fold changea	p
Aspa	Aspartoacylase	−1.99	0.0374b
CNP	2′,3′-cyclic nucleotide 3′ phosphodiesterase	−2.26b	0.0419b
EDG2	Lysophosphatidic acid receptor 1	−2.18b	0.0271b
Enpp2	Ectonucleotide pyrophosphatase/phosphodiesterase 2	−1.73	0.0345b
Erbb3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3	−1.92	0.0196b
Klk6	Kallikrein-related peptidase 6	−7.35b	0.0237b
MAG	Myelin-associated glycoprotein	−3.97b	0.0266b
MBP	Myelin basic protein	−4.68b	0.0189b
MAL	Myelin and lymphocyte protein, T-cell differentiation protein	−2.09b	0.0479b
MOBP	Myelin-associated oligodendrocytic basic protein	−3.15b	0.0132b
MOG	Myelin oligodendrocyte glycoprotein	−2.88b	0.0045b
Olig2	Oligodendrocyte transcription factor 2	−1.54	0.1581
Pllp	Plasma membrane proteolipid	−2.26b	0.0051b
Plp1	Proteolipid protein (myelin) 1	−2.30b	0.0097b
Pmp22	Peripheral myelin protein 22	−3.94b	0.0715

^aFold change represents Klotho^−/− compared with Klotho^+/+ as control. N = 4 for each group.

^bp < 0.05 and fold change > −2.