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. 2013 Feb 6;33(6):2313–2325. doi: 10.1523/JNEUROSCI.4965-11.2013

Figure 1.

Figure 1.

MKP-1 expression is decreased in HD systems. A, mRNA expression is significantly reduced in the striatum and cortex of R6/2 mice; expression of MKP-1 was significantly reduced at 8 (n = 8) and 10 weeks (n = 7) in R6/2 cortex and at 6 (n = 12), 8 (n = 6), and 10 weeks (n = 7) in R6/2 striatum compared with wild-type mice. Decreased MKP-1 mRNA expression was also detected in homozygous CHL2 “knock-in” HD mice at 15 months of age (n = 4). Significantly reduced levels of MKP-1 mRNA were also observed in primary cortical and striatal neurons expressing Htt171–82Q compared with neurons expressing Htt171–18Q (n = 6). Comparison with a noninfected control demonstrates that the expression difference between wild-type and polyglutamine-expanded Htt conditions was not the result of MKP-1 induction in 18Q cells (data not shown). MKP-1 mRNA downregulation was also observed in postmortem human HD Grade 0–1 caudate samples (n = 5) compared with age- and gender-matched controls (n = 5). B, A corresponding decrease of MKP-1 protein is demonstrated in striatal neurons expressing Htt171–82Q compared with striatal neurons expressing Htt171–18Q (n = 5). *p < 0.05 compared with control.