Table 3.

Single SNP associations with ischemic stroke under an additive model

		Familial Caucasian series (264 patients, 374 controls)			ISGS Caucasian series (449 patients, 334 controls)			Combined Caucasian series (713 patients, 708 controls)			ISGS African American series (166 patients, 117 controls)

SNP	MA^a	MAF	OR (95% CI)	P-value	MAF	OR (95% CI)	P-value	MAF	OR (95% CI)	P-value	MAF	OR (95% CI)	P-value
rs646776	C	19.8%	1.04 (0.79, 1.39)	0.77	23.2%	1.10 (0.85, 1.42)	0.49	21.7%	1.06 (0.88 – 1.27)	0.54	36.2%	0.79 (0.55, 1.15)	0.22
rs11206510	C	18.8%	1.01 (0.76, 1.34)	0.97	19.3%	0.93 (0.70, 1.23)	0.60	19.1%	0.99 (0.82 – 1.19)	0.89	12.2%	0.85 (0.48, 1.51)	0.58
rs6725887	C	12.8%	0.79 (0.56, 1.11)	0.17	11.8%	0.88 (0.62, 1.25)	0.48	12.2%	0.84 (0.67 – 1.06)	0.14	2.5%	0.94 (0.31, 2.87)	0.91
rs9818870	T	16.3%	0.84 (0.62, 1.13)	0.25	16.2%	0.87 (0.64, 1.17)	0.35	16.2%	0.84 (0.69 – 1.03)	0.090	10.1%	1.06 (0.56, 2.04)	0.85
rs12526453	G	35.2%	1.12 (0.87, 1.42)	0.38	33.0%	1.06 (0.84, 1.33)	0.65	34.0%	1.04 (0.89 – 1.23)	0.61	15.9%	1.21 (0.70, 2.08)	0.49
rs6922269	A	28.8%	0.81 (0.63, 1.03)	0.090	29.1%	1.28 (1.00, 1.65)	0.050	29.0%	1.01 (0.86 – 1.20)	0.87	53.4%	1.18 (0.81, 1.71)	0.40
rs2048327	C	34.8%	0.84 (0.66, 1.07)	0.15	35.2%	1.32 (1.03, 1.67)	0.026	35.0%	1.06 (0.91 – 1.25)	0.46	8.0%	0.79 (0.40, 1.55)	0.49
rs3127599	T	26.7%	1.02 (0.80, 1.32)	0.85	31.7%	1.17 (0.92, 1.48)	0.21	29.5%	1.08 (0.92 – 1.27)	0.36	28.3%	1.09 (0.71, 1.65)	0.70
rs7767084	C	17.0%	0.90 (0.67, 1.21)	0.49	15.5%	0.94 (0.69, 1.28)	0.69	16.2%	0.93 (0.75 – 1.14)	0.46	2.7%	0.68 (0.22, 2.12)	0.51
rs10755578	G	45.8%	0.88 (0.70, 1.10)	0.26	47.1%	1.21 (0.97, 1.52)	0.092	46.5%	1.02 (0.88 – 1.19)	0.80	33.0%	0.89 (0.59, 1.33)	0.56
rs1333040	C	41.0%	0.98 (0.78, 1.23)	0.88	38.0%	1.27 (1.01, 1.60)	0.040	39.3%	1.12 (0.96 – 1.30)	0.16	38.5%	0.65 (0.45, 0.94)	0.023
rs4977574	G	47.2%	0.95 (0.76, 1.18)	0.65	51.3%	0.90 (0.72, 1.12)	0.34	49.4%	0.93 (0.80 – 1.08)	0.32	20.5%	1.01 (0.64, 1.60)	0.98
rs1333042	A	50.8%	1.07 (0.86, 1.34)	0.52	46.9%	1.11 (0.89, 1.39)	0.34	48.7%	1.08 (0.93 – 1.26)	0.30	8.5%	0.55 (0.29, 1.05)	0.070
rs2383207	A	49.9%	1.07 (0.86, 1.33)	0.55	45.9%	1.09 (0.88, 1.36)	0.44	47.7%	1.07 (0.92 – 1.24)	0.38	8.5%	0.55 (0.29, 1.05)	0.070
rs1746048	T	14.4%	0.88 (0.64, 1.21)	0.42	12.4%	1.10 (0.77, 1.55)	0.61	13.3%	0.99 (0.79 – 1.24)	0.92	45.8%	1.17 (0.80, 1.70)	0.42
rs2259816	T	34.2%	0.88 (0.70, 1.11)	0.29	35.4%	1.14 (0.90, 1.44)	0.28	34.9%	1.00 (0.85 – 1.17)	0.99	13.1%	0.74 (0.43, 1.28)	0.28
rs1048990	G	16.9%	0.72 (0.52, 0.98)	0.038	15.6%	0.82 (0.60, 1.14)	0.24	16.2%	0.80 (0.64 – 0.99)	0.036	3.5%	0.31 (0.12, 0.83)	0.020
rs17228212	C	30.0%	1.24 (0.97, 1.60)	0.092	29.0%	0.80 (0.63, 1.02)	0.073	29.4%	1.02 (0.86 – 1.20)	0.83	13.6%	1.29 (0.74, 2.25)	0.38
rs1122608	T	25.5%	1.17 (0.92, 1.51)	0.20	26.2%	0.95 (0.74, 1.21)	0.66	25.9%	1.11 (0.94 – 1.31)	0.24	4.1%	0.91 (0.36, 2.32)	0.85
rs9982601	T	12.0%	0.82 (0.58, 1.17)	0.28	10.7%	1.13 (0.80, 1.61)	0.49	11.3%	0.97 (0.76 – 1.22)	0.77	25.8%	0.65 (0.42, 1.01)	0.055

The minor allele was considered to be the least frequent allele across all series’.

ORs and p-values result from logistic regression models adjusted for age and gender (Familial Caucasian series), age, gender, atrial fibrillation, coronary artery disease, diabetes, hypertension, and current smoking (ISGS Caucasian series), age, gender, and series (combined Caucasian series), and age, gender, coronary artery disease, diabetes, hypertension, and current smoking (ISGS African American series). ORs correspond to an additional minor allele.

SNP=single nucleotide polymorphism. MA=minor allele. MAF=minor allele frequency. OR=odds ratio. CI=confidence interval. ISGS=Ischemic Stroke Genetics Study.