Table 4.

Single SNP associations with ischemic stroke subtypes in the combined Caucasian series under an additive model

			Association with cardioembolic stroke (157 patients, 708 controls)		Association with large vessel stroke (157patients, 708 controls)		Association with small vessel stroke (141 patients, 708 controls)

SNP	MA^a	MAF	OR (95% CI)	P-value	OR (95% CI)	P-value	OR (95% CI)	P-value
rs646776	C	21.7%	0.96 (0.71 – 1.31)	0.80	1.07 (0.79 – 1.44)	0.68	0.94 (0.68 – 1.29)	0.69
rs11206510	C	19.1%	0.93 (0.68 – 1.29)	0.67	0.96 (0.70 – 1.31)	0.79	0.86 (0.61 – 1.21)	0.38
rs6725887	C	12.2%	0.79 (0.53 – 1.19)	0.26	0.76 (0.51 – 1.14)	0.18	0.81 (0.54 – 1.22)	0.31
rs9818870	T	16.2%	1.04 (0.74 – 1.45)	0.83	0.70 (0.49 – 1.01)	0.058	0.88 (0.62 – 1.25)	0.46
rs12526453	G	34.0%	0.82 (0.62 – 1.10)	0.18	1.04 (0.80 – 1.36)	0.78	1.07 (0.81 – 1.40)	0.64
rs6922269	A	29.0%	0.98 (0.74 – 1.31)	0.91	0.91 (0.69 – 1.21)	0.53	1.30 (0.98 – 1.73)	0.066
rs2048327	C	35.0%	1.20 (0.92 – 1.57)	0.19	1.07 (0.82 – 1.39)	0.61	0.99 (0.75 – 1.30)	0.93
rs3127599	T	29.5%	1.06 (0.80 – 1.39)	0.69	1.23 (0.94 – 1.61)	0.13	0.98 (0.73 – 1.30)	0.86
rs7767084	C	16.2%	0.98 (0.70 – 1.39)	0.93	0.76 (0.53 – 1.10)	0.14	1.02 (0.72 – 1.44)	0.90
rs10755578	G	46.5%	1.00 (0.77 – 1.29)	1.00	1.08 (0.84 – 1.38)	0.56	1.03 (0.80 – 1.34)	0.81
rs1333040	C	39.3%	1.55 (1.20 – 2.01)	0.0007	0.88 (0.68 – 1.14)	0.35	1.31 (1.01 – 1.69)	0.044
rs4977574	G	49.4%	0.69 (0.53 – 0.89)	0.0035	1.09 (0.85 – 1.39)	0.51	0.79 (0.61 – 1.03)	0.079
rs1333042	A	48.7%	1.42 (1.10 – 1.84)	0.0065	0.97 (0.76 – 1.24)	0.78	1.23 (0.95 – 1.58)	0.12
rs2383207	A	47.7%	1.39 (1.08 – 1.80)	0.010	0.95 (0.74 – 1.21)	0.68	1.22 (0.94 – 1.57)	0.13
rs1746048	T	13.3%	1.06 (0.72 – 1.56)	0.78	0.70 (0.47 – 1.06)	0.095	1.07 (0.73 – 1.55)	0.74
rs2259816	T	34.9%	1.14 (0.87 – 1.49)	0.34	1.00 (0.77 – 1.29)	0.99	1.08 (0.83 – 1.41)	0.55
rs1048990	G	16.2%	0.88 (0.61 – 1.26)	0.48	0.65 (0.44 – 0.94)	0.023	0.83 (0.57 – 1.20)	0.32
rs17228212	C	29.4%	1.10 (0.83 – 1.44)	0.52	0.97 (0.74 – 1.27)	0.80	1.15 (0.88 – 1.52)	0.31
rs1122608	T	25.9%	1.06 (0.79 – 1.41)	0.72	1.11 (0.84 – 1.46)	0.46	1.11 (0.83 – 1.48)	0.47
rs9982601	T	11.3%	1.06 (0.71 – 1.60)	0.77	1.09 (0.75 – 1.59)	0.67	1.17 (0.79 – 1.73)	0.43

The minor allele was considered to be the least frequent allele across all series’.

ORs and p-values result from logistic regression models adjusted for age, gender, and series. ORs correspond to an additional minor allele. SNP=single nucleotide polymorphism.

MA=minor allele. MAF=minor allele frequency. OR=odds ratio. CI=confidence interval.