Table 5.

Association of haplotypes of rs2048327-rs3127599-rs7767084-rs10755578 with overall ischemic stroke

	Haplotype frequency
Haplotype (rs2048327-rs3127599-rs7767084-rs10755578)	Ischemic stroke patients	Controls	P-value for association
Familial Caucasian series (264 patients, 374 controls)			0.72
C-C-T-G	2.4%	3.8%
C-C-C-G	15.3%	16.7%
C-T-T-G	12.6%	13.5%
C-C-T-C	2.2%	2.2%
T-T-T-G	13.2%	11.7%
T-C-T-C	52.3%	49.7%
ISGS Caucasian series (449 patients, 334 controls)			0.20
T-C-T-C	46.9%	51.2%
C-C-C-G	14.2%	14.3%
T-T-T-G	12.6%	13.4%
T-T-T-C	1.8%	2.0%
C-C-T-C	1.7%	1.6%
C-C-T-G	3.6%	2.2%
C-T-T-G	18.1%	13.8%
Combined Caucasian series (713 patients, 708 controls)			0.82
C-C-C-G	14.6%	15.6%
T-C-T-C	48.9%	50.3%
C-C-T-C	1.6%	1.5%
C-C-T-G	12.8%	12.5%
T-T-T-G	3.1%	3.0%
T-T-T-C	1.9%	2.0%
C-T-T-G	16.1%	13.7%
ISGS African American series (166 patients, 117 controls)			0.54
T-C-T-G	2.9%	5.4%
C-C-C-G	2.1%	3.0%
C-T-T-G	3.0%	2.3%
C-C-T-C	2.7%	2.1%
T-C-T-C	62.8%	61.9%
T-T-T-G	23.7%	23.7%
T-T-T-C	2.5%	0.9%

- P-values result from score tests of association. Haplotypes with a frequency of less than 1% were not considered. Adjustments were made for age and gender (familial Caucasian series), age, gender, atrial fibrillation, coronary artery disease, diabetes, hypertension, and current smoking (ISGS Caucasian series), age, gender, and series (combined Caucasian series), and age, gender, coronary artery disease, diabetes, hypertension, and current smoking (ISGS African American series).

ISGS=Ischemic Stroke Genetics Study.