Figure 8.
Systemic administration of the α2-adrenergic receptor agonist dexmedetomidine (100 μg/kg) prevents and reverses LPS (10 μg/kg)-evoked thermogenesis. Symbols represent the group means ± SEM of TBAT just before administration of LPS, at the time of LPS administration (time 0), and at 30 min intervals following injection of LPS. A, The change in TBAT following intraperitoneal injection of LPS preceded by an intraperitoneal injection of saline (open circles; n = 5) or dexmedetomidine (filled circles; n = 4). The asterisk indicates two-way repeated measures ANOVA: drug effect, p < 0.001; time effect, p < 0.001; and interaction effect, p < 0.001. B, The increase in TBAT following an intraperitoneal injection of LPS is reversed 1.5 h later by an intraperitoneal injection of dexmedetomidine (filled circles; n = 5) but not saline (open circles; n = 4). The asterisk indicates two-way repeated measures ANOVA: drug effect, p < 0.005; time effect, p < 0.001; interaction effect, p < 0.001.