Table 2.
Mean NMSC recurrence rates five years after treatment in clinical subgroups
| Characteristic | Recurrence rate [95% CI]1 | |||
|---|---|---|---|---|
| PATIENT CHARACTERISTICS | University Site n=857 | VA Site n=631 | Entire Sample n=1488 | |
| Age, years | < median of 69 years | 3.8% [1.9, 5.7] | 4.2% [1.3, 7.0] | 3.9% [2.3, 5.5] |
| ≥ median of 69 years | 2.4% [0.5, 4.4] | 2.8% [1.0, 4.7] | 2.7% [1.3, 4.0] | |
| Gender | Female | 3.2% [1.0, 5.3] | 0.0% [0.0, 20.6] | 3.0% [0.9, 5.0] |
| Male | 3.4 % [1.5, 5.2] | 3.5% [1.9, 5.2] | 3.5% [2.2, 4.7] | |
| Skin Type(Fitzpatrick, 1988) | Type I or II | 4.4% [1.2, 7.6] | 3.9% [0.5, 7.3] | 4.2% [1.8, 6.5] |
| Type III – VI | 3.5% [0.9, 6.0] | 3.5% [1.1, 5.9] | 3.5% [1.7, 5.2] | |
| Health Status (SF-12) | ||||
| Physical Component Score | < median of 48.7 | 5.3% [1.4, 9.2] | 2.3% [0.3, 4.4] | 3.5% [1.5, 5.4] |
| ≥ median of 48.7 | 2.8% [0.6, 5.0] | 4.4% [0.5, 8.1] | 3.4% [1.4, 5.3] | |
| Mental Component Score | < median of 51.5 | 3.4% [0.4, 6.2] | 5.3% [1.6, 8.9] | 4.3% [2.0, 6.6] |
| ≥ median of 51.5 | 4.2% [1.3, 7.0] | 1.1% [0, 2.6] | 2.7% [1.0, 4.4] | |
| Comorbidity (Charlson index) | < median of 1 | 2.4% [0.0, 4.7] | 6.1% [1.2, 10.7] | 3.8% [1.4, 6.0] |
| ≥ median of 1 | 5.0% [1.9, 8.1] | 2.5% [0.6, 4.4] | 3.6% [1.9, 5.2] | |
| History of prior NMSC | No history | 2.0% [0.4, 3.6] 3 | 2.6% [0.3, 4.8] | 2.3% [0.9, 3.6] 2 |
| History | 4.5% [2.2, 6.8] | 4.0% [1.7, 6.2] | 4.3% [2.7, 5.8] | |
| History of organ transplantation | No history | 3.4% [2.0, 4.9] | 3.5% [1.8, 5.2] | 3.5% [2.4, 4.6] |
| History | 0.0% [0.0, 12.8] | 0.0% [0.0, 23.2] | 0.0% [0.0, 8.6] | |
| History of HIV | No history | 2.5% [1.2, 3.8] 4 | 3.1% [1.5, 4.6] 4 | 2.8% [1.8, 3.7] 4 |
| History | 19.6%[4.0, 32.7] | 27.1%[0.0, 53.2] | 20.8%[6.6, 32.9] | |
| Number of NMSCs at presentation: | ≤ median of 1 | 1.9% [0.6, 3.3] 4 | 2.0% [0.5, 3.4] | 2.0% [1.0, 2.9] 4 |
| > median of 1 | 5.8% [2.7, 8.9] | 5.9% [2.2, 9.4] | 5.9% [3.5, 8.2] | |
| TUMOR CHARACTERISTICS | n=857 | n=631 | n=1488 | |
| Histological Type: | BCC | 3.3% [1.7,4.8] | 3.5% [1.6, 5.4] | 3.4% [2.1, 4.6] |
| SCC | 3.3% [0.4, 6.2] | 3.1% [0.0, 6.0] | 3.2% [1.1, 5.2] | |
| High-risk Histological Features(NCCN,2011): | No high-risk features | 3.9% [2.2, 5.7] | 3.6% [1.8, 5.5] | 3.8% [2.5, 5.0] |
| High-risk features | 1.2% [0.0, 2.9] | 2.3% [0.0, 5.4] | 1.6% [0.0, 3.1] | |
| Tumor Diameter, mm: | < median of 8 mm | 4.0% [1.5, 6.3] | 2.8% [0.3, 5.3] | 3.5% [1.7, 5.3] |
| ≥ median of 8 mm | 2.7% [0.8, 4.6] | 3.3% [1.0, 5.5] | 3.0% [1.5, 4.4] | |
| Tumor present in the `H-zone' of the face: | Not present | 3.7% [1.9, 5.4] | 3.0% [1.0, 5.0] | 3.4% [2.1, 4.8] |
| Present | 2.4% [0.3, 4.5] | 4.0% [1.2, 6.6] | 3.2% [1.5, 4.9] | |
| CARE CHARACTERISTICS | ||||
| Training Level of Treating Clinician: | Attending physician | 3.4% [1.9, 4.8] | 2.2% [0.0, 4.6] | 3.1% [1.8, 4.3] |
| Resident physician | 0.0% [0.0, 9.3] | 4.2% [1.9, 6.5] | 3.8% [1.7, 5.8] | |
| Nurse practitioner | Not applicable | 4.2% [0.0, 11.8] | Not applicable | |
| Treatment of NMSC: | Destruction | 6.2% [2.5, 9.6] 2 | 2.8% [0.0, 6.0] | 4.9% [2.3, 7.4] |
| Excision | 2.6% [0.3, 4.9] | 4.2% [1.7, 6.6] | 3.5% [1.8, 5.2] | |
| Mohs surgery | 1.9% 0.2, 3.5] | 2.4% [0.0, 5.1] | 2.1% [0.6, 3.5] | |
| Number of Annual Visits to Dermatology: | ≤ 2 visits | 2.0% [0.7, 3.3] 4 | 2.3% [0.3, 4.4] | 2.1 % [1.0, 3.2] 4 |
| > 2 visits | 6.6% [2.8, 10.2] | 4.3% [1.9, 6.7] | 5.2% [3.1, 7.2] | |
1
P values refer to comparisons of subgroups within each column.
2
0.05 ≤ P ≤ 0.10
3
0.01 ≤ P< 0.05
4
P< 0.01