Figure 4.

Model for binding of FAAP24 HhH domain to dsDNA. From left to right, following figures are presented: model of the FAAP24 HhH domain bound to dsDNA, based on structural similarity (Z-score: 3.7) of FAAP24 HhH domain (green) with DNA polymerase ι [3gv5; (42)]. (blue). Surface representation indicating sequence conservation calculated as in Figure 1D. For indicating hydrophobicity, side chains of hydrophobic residues are colored in orange. For charge, the surface is colored according to the electrostatic surface potential, calculated using APBS (43) (blue: positive, red: negative). The right panel shows determined dsDNA-binding surface colored as described in Figure 3.