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. 2013 May 8;41(13):6664–6673. doi: 10.1093/nar/gkt352

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© The Author(s) 2013. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — (A) Base triples studied in this article. The N3 atom of C base needs to be protonated (shown in bold) to form C⁺·G–C base triple. The s²U·A–U base triple is more stable than unmodified U·A–U base triple because of enhanced van der Waals interaction between the thio group in 2-thio U and H8 hydrogen (shown in bold) in A and other molecular interactions. (B) Chemical structures of nucleosides: RNA U (U), 2′-OMe U (U^M), LNA U (U^L), 2-thio U (s²U) and 2′-OMe 2-thio U (s²U^M).