. 2013 May 8;41(13):6664–6673. doi: 10.1093/nar/gkt352

Table 1.

TFO sequences studied in this article

TFO	Sequence (5′–3′)^a
1-D12^b	T	C	T	C	T	C	T	C	T	T	T	C
1-R12	U	C	U	C	U	C	U	C	U	U	U	C
Control	A	U	C	U	G	U	U	C	C	A	C	U
1-RU^L1	U	C	U	C	U	C	U^L	C	U	U	U	C
1-RU^L2	U	C	U	C	U^L	C	U^L	C	U	U	U	C
1-RU^L3	U	C	U	C	U^L	C	U^L	C	U^L	U	U	C
1-Rs²U1	U	C	U	C	U	C	s²U	C	U	U	U	C
1-Rs²U2	U	C	U	C	s²U	C	s²U	C	U	U	U	C
1-Rs²U3	U	C	U	C	s²U	C	s²U	C	s²U	U	U	C
1-RU^M3	U	C	U	C	U^M	C	U^M	C	U^M	U	U	C
1-M12	U^M	C^M	U^M	C^M	U^M	C^M	U^M	C^M	U^M	U^M	U^M	C^M
1-MU^L1	U^M	C^M	U^M	C^M	U^M	C^M	U^L	C^M	U^M	U^M	U^M	C^M
1-MU^L2	U^M	C^M	U^M	C^M	U^L	C^M	U^L	C^M	U^M	U^M	U^M	C^M
1-MU^L3	U^M	C^M	U^M	C^M	U^L	C^M	U^L	C^M	U^L	U^M	U^M	C^M
1-Ms²U^M1	U^M	C^M	U^M	C^M	U^M	C^M	s²U^M	C^M	U^M	U^M	U^M	C^M
1-Ms²U^M2	U^M	C^M	U^M	C^M	s²U^M	C^M	s²U^M	C^M	U^M	U^M	U^M	C^M
1-Ms²U^M3	U^M	C^M	U^M	C^M	s²U^M	C^M	s²U^M	C^M	s²U^M	U^M	U^M	C^M
3-R12	C	C	U	C	U	C	C	U	C	C	C	U
3-Rs²U2	C	C	U	C	s²U	C	C	s²U	C	C	C	U
3-RU^L2	C	C	U	C	U^L	C	C	U^L	C	C	C	U

^aAll listed sequences have RNA residues unless otherwise noted. The modified nucleotides studied are LNA U (U^L), 2-thio U (s²U), 2′-OMe U (U^M), 2′-OMe C (C^M) and 2′-OMe 2-thio U (s²U^M). In the nomenclature for TFOs, the first number (1 or 3) indicates the TFO’s complementary hairpin sequence (rHP1, dHP1 or rHP3), and the last number (1, 2, 3 or 12) indicates the number of modified residues. The first letters (D, R and M) indicate the main backbone compositions of DNA, RNA and 2′-OMe RNA, respectively.

^bIn TFO 1-D12, all 12 residues are unmodified deoxyribonucleotides.