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. Author manuscript; available in PMC: 2013 Jul 15.
Published in final edited form as: Arch Neurol. 2011 Jun;68(6):814–821. doi: 10.1001/archneurol.2011.110

Figure 2. Abnormal internodes in skin biopsies from the patient with PMP22 null.

Figure 2

Figure 2

Figure 2

(A&B) Immunohistochemistry using MBP (red) and PGP9.5 (green) antibodies reveals multiple MBP-positive Schwann cells (red) surrounding axons (green) without forming internodes in dermal myelinated fibers in the patient’s skin sample. In A, red channel gain was artificially increased to highlight MBP positive Schwann cells. In B, the same image as A with the green channel gain increased to highlight PGP9.5 positive axons. (C) A control skin biopsy discloses normal internode of dermal myelinated fibers flanked by MBP negative regions corresponding to nodes of Ranvier. Scale bar = 10 um.