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Bradykinin-induced Cl− currents are partially mediated by CaMKII activation of ClC-3. A, Time to BK-induced peak depolarization after inhibition of CaMKII with AIP and knockdown of ClC-3. B, Peak late-phase voltage change (millivolts) after inhibition of CaMKII with AIP and knockdown of ClC-3. C, D, BK-induced current–voltage changes during late-phase response. CaMKII or ClC-3 inhibition decreases bradykinin-induced Cl− currents. n = 15 cells; *p < 0.05.
