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. 2013 Jan 23;33(4):1577–1588. doi: 10.1523/JNEUROSCI.1749-12.2013

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Copyright © 2013 the authors 0270-6474/13/331577-12$15.00/0

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Figure 5. — AAV-GluA1-shRNA-mediated downregulation of CeA GluA1 subunits inhibits associative learning of morphine reward. A, Western blotting analysis of CeA synaptosomal GluA1 (GA1) and GluA2 proteins in rats (n = 6/group) with bilateral CeA injection of AAV-GluA1-shRNA or AAV-scrambled (Scr) shRNA. CeA tissues were collected at post-injection day 10. **p < 0.01. B, Representative micrographs of GluA1 immunoreactivity and GFP expression in CeA neurons from a rat after CeA injection of AAV-scrambled shRNA (a–c) or AAV-GluA1-shRNA (d–f). Scale bars, 50 μm. C, CPP behaviors in rats with bilateral CeA injection of AAV-scrambled shRNA or AAV-GluA1-shRNA after multiple conditioning sessions with saline (n = 6 rats/group) or morphine (3 mg/kg, n = 10 rats/group), followed by daily conditioning sessions of extinction training. *p < 0.05 (compared to the pretest in the same group); ^#p < 0.05 (compared to the morphine/scrambled shRNA group).