Fig. 2.

Chloroquine preferentially blocks outward current through WT and mutant Kir2.1 channels. Top panel, WT and mutant Kir 2.1 current elicited by 4 s pulses from a holding potential of −80 mV to test potentials from −120 to −20 mV, applied in 10 mV increments, in absence and presence of chloroquine 10 µM. B, Normalized current-voltage relationship for currents measured at the end of 4 s pulses for control and indicated concentrations of chloroquine.