Table 1.

Electrophysiological properties of simulated WT, homozygous (D172N) and heterozygous (WT-D172N) ventricular myocytes. APD₉₀ and APD₅₀, action potential duration at 90% and 50% repolarization, respectively. [CQ], chloroquine concentration. ERP, effective refractory period.

	WT	D172N	WT/D172N
APD90 (s)
[CQ]
0	0.383	0.342	0.358
1	0.402	0.354	0.371
3	0.430	0.368	0.387
10	0.528	0.395	0.419
APD50 (s)
[CQ]
0	0.340	0.331	0.338
1	0.341	0.337	0.341
3	0.341	0.340	0.343
10	0.338	0.342	0.342
Max IK1 (pA/pF)
[CQ]
0	3.15	13.80	10.51
1	1.78	7.80	5.94
3	0.95	4.18	3.18
10	0.36	1.59	1.21
ERP (s)
[CQ]
0	0.385	0.340	0.360
1	0.405	0.355	0.373
3	0.425	0.370	0.388
10	0.377	0.393	0.415