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Effects of gadolinium ion and reducing external Na+ on the SubP-induced depolarization of pacemaking activity in cultured ICC clusters. (A) Effect of gadolinium ion (Gd3+) on SubP– induced response of pacemaking activity. (B) Effects of SubP in the presence of 5 mM of external Na+ in pacemaking activity. Population data for the manipulations shown in left is expressed as the amplitude of depolarization. Values are mean ± SEM.
