Figure 10.

Celf6^−/− mice show decreased brain serotonin levels. LC-MS/MS measures of levels of neuromodulatory neurotransmitters serotonin (5HT), norepinephrine (NE), and dopamine (DA) reveal a significant decrease (**p < 0.002) in 5HT levels, and nonsignificant trend for NE and DA in whole brains from n > 7 WT and Celf6^−/− mice. There is no change in the negative control transmitters GABA and glycine. Data are plotted as a percentage of WT ion count levels; error bars represent SEM. Tables provide absolute levels in pMol.