Figure 8.

Adult Celf6^−/− mice exhibit control-like levels of sociability, social preference, and anxiety-like behaviors. A, During the first social approach test, adult Celf6^−/− and WT mice both showed normal sociability preference for a novel stimulus mouse over an empty withholding cage during the test trial (rmANOVA with planned comparisons, *p < 0.00004). B, During the second social approach test, adult Celf6^−/− mice spent more time investigating the cagemate compared with the empty withholding cage during test trial 1 (**p < 0.005), demonstrating no deficits in sociability toward a familiar cagemate. During test trial 2, adult Celf6^−/− and WT mice both displayed a preference for social novelty by spending more time investigating the novel stimulus mouse compared with a familiar cagemate during test trial 2 (rmANOVA with planned comparisons, *p < 0.0003). C, D, Adult Celf6^−/− and WT mice showed similar levels of anxiety-like behaviors as indexed by the amount of time spent (C) and distance traveled (D) in the open arms of the elevated plus maze. Data are mean ± SEM.