Figure 2.

Tau reduction significantly decreases seizure frequency in Kcna1^−/− mice. A, Representative spontaneous cortical seizure recorded bilaterally in a Kcna1^−/− mouse during chronic in vivo EEG monitoring. B, Analysis of seizures/h in double-mutant mice recorded for 9 or more hours. Both tau reduction and loss significantly decreased seizure frequency in Kcna1^−/−Tau^+/− (n = 8) and Kcna1^−/−Tau^−/− (n = 8) double mutants compared with Kcna1^−/−Tau^+/+ (n = 8). Seizures were observed in 5/8 Kcna1^−/−Tau^+/+ mice, 0/8 Kcna1^−/−Tau^+/− mice, and only 1/8 Kcna1^−/−Tau^−/− mice. Total deletion of tau reduced the average seizure frequency by >94%. *p < 0.05; Kruskal–Wallis; error bars represent SEM.