Figure 6.

Presynaptic Fmr1 deletion causes reduced release probability. A, Individual examples of use-dependent NMDAR blockade by MK-801. Curves are best fits of the data to single exponential decay functions. Inset, Average NMDAR-mediated uEPSCs acquired during baseline measurement. Calibration: 10 pA, 40 ms. B, Binned and averaged responses from each individual experiment were then averaged across all experiments (see Materials and Methods). Four intervals are higher in the KO data (two-way ANOVA followed by multiple comparisons; WT, n = 8; KO, n = 6). C, The average time constant derived from each individual experiment is longer with presynaptic Fmr1 deletion. *p < 0.05; **p < 0.01.