Table 4.
Multiple SNP and Clinical Factor Analysis for Association with the Development of Mycophenolate Related Anemia
| Clinical Factors and SNPs | Hazard Ratio (95% CI)1 |
|---|---|
| Antiviral prophylaxis | 1.89 (0.84–4.25) |
| Decade of age2 | 1.28 (1.09–1.50) |
| Weight | 0.99 (0.98–1.00) |
| Weight squared3 | 1.00 (1.00–1.001) |
| Posttransplant dialysis4 | 2.44 (1.41–4.20) |
| rs1056663 (HUS1)5 | 0.55 (0.40–0.77) |
| rs568408 (IL12A)6 | 1.84 (1.28–2.66) |
| rs11572076 (CYP2C8) | 2.62 (1.34–5.10) |
1
CI is 95% confidence interval,
2
1.28 (28%) increase in hazard of anemia for every decade increase from the mean age,
3
square term for the mean-centered weight,
4
receipt of dialysis is a 2.44 greater hazard than not receiving dialysis,
5
HUS1 was protective against anemia with a hazard of 0.55 (45% reduction) of developing anemia for one allele relative to those recipients without the SNP.
6
IL12A increases hazard of anemia by 1.84 (84%) for every one allele relative to those recipients without the SNP.