Table 5.

Adjusted and Unadjusted Single SNP Analysis Towards Mycophenolate Related Leukopenia

SNP no.	rs number	Gene Name	Unadjusted Hazard Ratio (95% CI)1,2	p-value	Adjusted Hazard Ratio (95% CI)2,3	p-value	MAF4
1	rs1041163	VCAM15	0.58 (0.43–0.77)	0.00023	0.60 (0.44–0.81)	0.0008	C	0.17
2	rs2392221	VCAM15	0.55 (0.40–0.77)	0.00038	0.59 (0.42–0.82)	0.0016	T	0.15
3	rs4149056	SLCO1B1	1.46 (1.14–1.87)	0.00283	1.52 (1.17–1.98)	0.0017	C	0.13
4	rs9658655	CHGA	0.52 (0.35–0.77)	0.00089	0.54 (0.36–0.79)	0.0017	C	0.10
5	rs12418	CHST3	1.28 (1.07–1.53)	0.00726	1.34 (1.11–1.62)	0.002	A	0.43
6	rs10759326	IKBKAP6	1.33 (1.09–1.64)	0.00583	1.40 (1.13–1.73)	0.002	G	0.26
7	rs4148950	CHST37	1.28 (1.07–1.53)	0.00756	1.32 (1.1–1.6)	0.003	A	0.43
8	rs10979601	IKBKAP6	1.31 (1.07–1.61)	0.00932	1.37 (1.11–1.7)	0.004	T	0.25
9	rs2020870	FMO2	0.46 (0.29–0.74)	0.00131	0.50 (0.31–0.81)	0.004	G	0.07
10	rs9282626	CAT	1.67 (1.17–2.40)	0.00489	1.71 (1.18–2.47)	0.004	C	0.05
11	rs5744934	POLE	1.48 (1.15–1.91)	0.00246	1.47 (1.12–1.91)	0.005	G	0.12
12	rs4148947	CHST37	1.26 (1.05–1.52)	0.01225	1.31 (1.08–1.58)	0.005	C	0.43
13	rs2140516	SLC13A1	1.30 (1.08–1.58)	0.00638	1.32 (1.09–1.61)	0.006	C	0.31
14	rs7201683	WWOX	1.68 (1.11–2.55)	0.01413	1.81 (1.19–2.76)	0.006	G	0.03
15	rs6941583	POLH	1.36 (1.03–1.81)	0.03209	1.49 (1.12–1.99)	0.006	T	0.08
16	rs2706338	RAD50	1.33 (1.07–1.65)	0.01020	1.35 1.08–1.68)	0.007	T	0.18
17	rs1058172	CYP2D6	0.69 (0.49–0.96)	0.02809	0.62 (0.44–0.88)	0.008	A	0.13
18	rs769214	CAT	0.72 (0.59–0.88)	0.00168	0.76 (0.62–0.93)	0.009	G	0.36

¹SNPs are not adjusted for clinical factors,

²hazard and 95% confidence interval (CI) of developing leukopenia for each risk allele,

³Adjusted for corticosteroid use, weight, prior kidney transplant, donor (living vs deceased), CMV serostatus,

⁴allele associated with the hazard and minor allele frequency (MAF) in the population,

⁵VCAM1 SNPs are correlated r²=0.78,

⁶IKBKAP SNPs are correlated r²=0.97,

⁷CHST3 SNPs are correlated r²=0.997.