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. 2013 Jan 2;33(1):187–200. doi: 10.1523/JNEUROSCI.3214-12.2013

Figure 4.

Figure 4.

Functional characterization of isolated or dual Syt1 C2 domains on synchronous release. A, Representative eEJPs recorded in the presence of high [Ca2+]o (1.0 mm) are shown for wild-type and syt1−/− rescued with the indicated transgenic constructs. B, Mean amplitude of eEJP responses are indicated for each genotype. The mean eEJP amplitude for wild-type and syt1 null mutants (compare Fig. 3B) are indicated with black and light gray dotted lines, respectively. Data are mean ± SEM. ***p < 0.001, one-way ANOVA with multiple comparisons using the Fisher's LSD test between syt1−/− rescued with the C2A-C2B (Fig. 3) and the indicated genotypes. Number of NMJs examined: syt−/−, C2A-C2B, 11; syt−/−, C2A, 6; syt−/−, C2B, 5; syt−/−, C2A-C2A, 7; and syt−/−, C2B-C2B, 13.