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. 2013 Jan 9;33(2):495–506a. doi: 10.1523/JNEUROSCI.3710-12.2013

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Copyright © 2013 the authors 0270-6474/13/330495-12$15.00/0

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Figure 5. — Intra-vmPFC pretreatment with mGluR-targeting compounds produces residual effects on cue-reinforced responding in cocaine-experienced animals. A, When tested for cue-reinforced behavior 24 h after an intra-vmPFC infusion of 3.0 μg/side MTEP before initial testing for cue-reinforced behavior (MTEP PreRx) or an intra-vmPFC infusion of 30 pg/side JNJ 16259685 either before (JNJ PreRx) or immediately after (JNJ PostRx) the initial test for cue-reinforced behavior in the absence of any additional intracranial manipulation, VEH-pretreated rats exhibited reduced responding (extinction), whereas no behavioral extinction was apparent in animals pretreated or posttreated with mGluR antagonists. B, In contrast to the vmPFC, intra-dmPFC pretreatment with 30 pg/side JNJ 16259685 failed to influence behavioral extinction at 3 d withdrawal. C, Interestingly, when assayed at 30 d withdrawal, VEH-pretreated rats exhibited no sign of behavioral extinction when tested for cue-reinforced behavior, whereas extinction was facilitated in cocaine-experienced animals pretreated with 27 ng/side DHPG. Sample sizes are indicated in parentheses. *p < 0.05 versus test 1. ⁺p < 0.05, main effect of test. WD, Withdrawal.