Fig. 4.

Measurements of inhibition of [³H]dopamine and [³H]serotonin uptake by desipramine for human DAT and SERT mutants in HEK-293 cells. Wild-type (WT) hDAT, hSERT and various mutant constructs are denoted on the left. Results are expressed as percent of uptake measured with vehicle (% control). Data are shown as mean ± SEM (horizontal bars, N = 3–5). Asterisk indicates P < 0.05 (compared with corresponding WT at the same concentration of desipramine, one-way analysis of variance followed by Dunnett multiple comparison test for hDAT, and Student’s t-test for hSERT).