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ΔCR neurons in cerebellar slices show ultrastructural features reminiscent of excitotoxic cell death. Electron micrographs of the cerebellar granule layer in slices cultures kept in culture for 15 d before fixing and embedding. Note the heterogeneously condensed chromatin in granule cell nuclei of ΔCR/PrP+/− mice (B) that is not present in granule cell nuclei of PrP+/− (A) or ΔCR/Tga+/−/PrP+/− (C) animals (see insets). Scale bar, 2 μm.
