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. 2012 Oct 31;32(44):15271–15276. doi: 10.1523/JNEUROSCI.2034-12.2012

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Figure 2. — APP and Aβ levels are not significantly altered by reduction of Synj1 in Tg2576 mice. A, Western blot detection of human APP (6E10), Synj1, and anti-neuronal β-tubulin (TUJ1) from brain of WT (n = 6), Synj1^+/− (n = 7), Tg2576/Synj1^+/+ (n = 5) and Tg2576/Synj1^+/− (n = 7) mice. B, APP levels as normalized to TUJ1. C, Synj1 levels as normalized to TUJ1. D, Detection of Aβ42 and Aβ40 from brain of Tg2576/Synj1^+/+ (n = 5) and Tg2576/Synj1^+/− (n = 7) mice. E, Inositol lipid levels from synaptosome-enriched (P2) fractions derived from forebrain tissue of WT (n = 9), Synj1^+/− (n = 6), Tg2576/Synj1^+/+ (n = 6), and Tg2576/Synj1^+/− (n = 6) mice, as determined by HPLC combined with suppressed conductivity.