Figure 8.
Proportion of CA1 cells that expressed Arc across the different age groups and behavioral conditions. The y-axis shows the proportion of distal (purple) and proximal (orange) CA1 cells that were positive for Arc mRNA (in any cellular compartment) as a function of age group and experimental condition (AA, AB, CC, or MECS). Behavioral condition (but not age) significantly affected the proportion of cells that expressed Arc (repeated-measures ANOVA, F(3,39) = 60.15, p < 0.001). Specifically, rats in the MECS condition had a significantly higher percentage of Arc-positive CA1 pyramidal cells than did the rats in the other three conditions (Tukey's HSD test, p < 0.001 for all comparisons). Moreover, rats in the CC condition had significantly lower normalized numbers of Arc-positive neurons in CA1 relative to the rats in both the AA and AB conditions (Tukey's HSD test, p < 0.001 for all comparisons). Error bars indicate ± 1 SEM.